NCSTN and Alzheimer disease: It is important to note that the glycosylation of nicastrin is reliant on the two presenilin catalytic subunits of γ-secretase (PSEN1 and PSEN2) and, considering its involvement in the substrate interactions of the cleaving enzyme (Yang et al., 2002), analyzing glycan structures in nicastrin and their possible impact on AD pathogenesis seems to be a promising objective to be worked on.