Chemokine ligands such as C-C motif chemokine ligand (CCL) 2 (CCL2), CCL3, CCL4, CCL13, CCL19, CCL21, chemokine C-X-C motif ligand (CXCL) 9 (CXCL9), CXCL10, CXCL16 and receptors C-C motif chemokine receptor (CCR) 1 (CCR1), CCR5, and CXCR6 were all identified as changing in the RPE of AMD patients (Saddala et al., 2019). This evidence concerns the gene CCL2 and age-related macular degeneration.