Mice lacking Ccl2, which is important for RPE recruitment of MPs (Ambati et al., 2003; Vessey et al., 2015); P2X7-receptor, which is important for MP phagocytosis (Vessey et al., 2017); and Cx3cr1 – mouse study not human, which is expressed solely by MPs (Combadière et al., 2007), all show subretinal microglia associated with RPE damage and retinal dysfunction that is reminiscent of early AMD in aged animals relative to age-matched controls. Here, P2RX7 is linked to age-related macular degeneration.