CCR5 and age-related macular degeneration: CCR5 expression was low on monocytes of healthy controls as it is generally not expressed under homeostatic conditions (Krogh Nielsen et al., 2020), but an increase in expression on monocytes has been shown to occur during acute inflammation (Castanheira et al., 2019), suggesting a role for this chemokine receptor in ongoing inflammatory response in late-stage AMD.