Another study, which did not isolate RPE specifically, but microdissected regions of photoreceptor and RPE cells from lesion areas of both GA and nAMD and healthy control samples, also found increases in mRNA expression of NLRP3, pro-IL-1β and pro-IL-18 in late-stage AMD (Wang et al., 2016). This evidence concerns the gene NLRP3 and age-related macular degeneration.