CCL2 and age-related macular degeneration: Mice lacking Ccl2, which is important for RPE recruitment of MPs (Ambati et al., 2003; Vessey et al., 2015); P2X7-receptor, which is important for MP phagocytosis (Vessey et al., 2017); and Cx3cr1 – mouse study not human, which is expressed solely by MPs (Combadière et al., 2007), all show subretinal microglia associated with RPE damage and retinal dysfunction that is reminiscent of early AMD in aged animals relative to age-matched controls.