The pathological hallmarks of AD include deposition of amyloid beta (Aβ) plaques and tau neurofibrillary tangles (Nisbet et al., 2015; Morgese et al., 2017), decrease in brain acetylcholine (ACh), overexpression of acetylcholinesterase (AChE), and glutamate excitotoxicity (Francis, 2005). The gene discussed is ACHE; the disease is Alzheimer disease.