The results of this study showed that HHAE significantly reduced the expression levels of p38 MAPK, PI3K, Akt, and VEGF mRNA and protein in lung tissue of asthmatic mice, suggesting that the mechanism of HHAE alleviating asthma inflammation is related to the inhibition of the p38 MAPK/PI3K signaling pathway. The gene discussed is VEGFA; the disease is asthma.