These kinetics are typical of acute malaria parasite infections, denoting a switch from a pro- to anti-inflammatory systemic response to protect the host from immunopathology, driven in part by the co-production of IFNɣ+ and IL-10+ in activated T cells (Couperet al., 2008a;Couperet al., 2008b;do Rosárioet al., 2012). The gene discussed is IFNA1; the disease is parasitic infectious disease.