AKT1 and major depressive disorder: Kaempferol was also found to increase the activity of P-serine/threonine protein kinase (AKT) and β-catenin, but after using PI3-K inhibitors, the overall protective effect mediated by kaempferol was partially inhibited, indicating that kaempferol can enhance the antioxidant capacity and anti-inflammatory effects by enhancing the activity of the AKT/β-catenin cascade, thereby treating depression [21].