TLR4 and depressive disorder: In a neuropathic pain mouse model, Bai et al. found that paeoniflorin can significantly improve the hyperalgesia and depression-like behavior of mice, reduce the level of proinflammatory cytokines, inhibit the excessive activation of microglia, and reduce the pathological damage of hippocampal cells in a way that is similar to the inhibition of the expression of TLR4/NF-κB pathway related proteins [30].