BDNF and major depressive disorder: There are also reports showing that in olfactory bulbectomy-induced animal depression models, PCA can shorten the immobility time of rats in the OFT, increase the distance explored in the OFT, increase rat hippocampal monoamine neurotransmitters (5-HT, DA, and norepinephrine) and BDNF levels, reduce hippocampal CORT levels, and alleviate hippocampal neuroinflammation and oxidative damage [58].