In a mouse depression model induced by LPS, Cheng et al. found that paeoniflorin can inhibit LPS-induced TLR4/NF-κB/NLRP3 signaling in the hippocampus of mice, reduce the level of proinflammatory cytokines and microglia activation, and at the same time, increase neuronal FGF2 levels and dendritic spine density [29]. Here, NFKB1 is linked to major depressive disorder.