There is evidence that in CUMS-induced animal depression models, hippocampal LTP is impaired, and Liu et al. found that administration of paeoniflorin can alleviate LTP injury in the hippocampal CAI area and increase both the density of hippocampal dendritic spines and the expression levels of BDNF and PSD95 [83]. Here, DLG4 is linked to major depressive disorder.