It has been reported that Saponin D can downregulate the expression of NF-κB in rat hippocampal neurons and improve the depression-like behavior induced by chronic unpredictable mild stress (CUMS) by downregulating Mir-155 expression and upregulating fibroblast growth factor 2 (FGF2) expression [18]. This evidence concerns the gene NFKB1 and major depressive disorder.