CDH2 and cancer: Moreover, its overexpression is closely associated with accelerated tumour growth, invasion, and poor prognosis [49]; α-SMA was confirmed to be highly expressed in breast cancer [50]; aberrant expression of N-cadherin has been found in many cancers, and its abnormal expression is closely related to the transformation, adhesion, apoptosis, angiogenesis, invasion, and metastasis of human malignancies [51].