NQO1 and nasopharyngeal carcinoma: In nasopharyngeal carcinoma (NPC), the significant down-regulation of Raf kinase inhibitor protein (RKIP) leads to the down-regulation of miR-450b-5p, thus activating NRF2/NQO1 signaling pathway and inhibiting ferroptosis process, which promotes NPC resistance to radiation (Huang et al., 2020).