In addition, circKIF4A/miR-1231/GPX4 axis in papillary thyroid cancer (Chen W.et al., 2021), miR-15a/GPX4 axis in prostate cancer (Xu et al., 2022), circIL4R/miR-541-3p/GPX4 axis in hepatocellular carcinoma (Xu et al., 2020) and circDTL/miR-1287-5p/GPX4 axis in non-small cell lung cancer (NSCLC) (Shanshan et al., 2021) also regulate the process of ferroptosis in corresponding tumors. This evidence concerns the gene GPX4 and Familial prostate cancer.