In the case of intracellular iron deficiency, ferritin can also be transported to autophagosome under the action of nuclear receptor coactivator 4 (NCOA4), and ferritin will release Fe3+ again due to autophagy; When cells are not iron deficient, ferritin is degraded through non autophagy (Asano et al., 2011; Mancias et al., 2014). The gene discussed is NCOA4; the disease is nutritional disorder.