In the study of the regulation of breast cancer cell proliferation, metastasis and ferroptosis by circular RNA RHOT1 (cirRHOT1), it was found that cirRHOT1 could adsorb miR-106a-5p and reduce its expression, weaken the inhibition of miR-106a-5p on STAT3, and finally enhance the resistance of MDA-MB-231 and T47D breast cancer cells to ferroptosis. The gene discussed is STAT3; the disease is breast cancer.