The most frequent AEs were polyuria, the proportion of neutrophils decreased, fecal occult blood (positive for transferrin), neutrophil count decreased, white blood cell count decreased and creatinine increased, most of which were more common with the higher doses, and have previously been reported in healthy subjects or patients treated with JAK inhibitors (Shi et al., 2014; Taylor et al., 2017; Li et al., 2022). The gene discussed is TF; the disease is Polyuria.