Among them, ESR (22.50 (13.00,47.00) vs. 9.00 (5.00,14.00) mm/h) and CRP (6.92 (2.01,13.05) vs. 2.89 (1.33,3.56) mg/L) in SSc were higher compared with HCs. The gene discussed is CRP; the disease is systemic sclerosis.