P2RY6 and Hypertension: In addition, P2Y6 receptors are involved in the signaling of peripheral blood mononuclear cells (Campwala et al., 2014), control arteriolar myogenic tone (Kauffenstein et al., 2016), and heterodimerize with angiotensin AT1 receptors to support the development of hypertension (Nishimura et al., 2016).