The upregulation of Ang II contributes to DKD progression by activating proinflammatory and profibrotic effects (Yang et al., 2016b; Chen L. et al., 2017), while recombinant ACE2 attenuates DKD progression by suppressing oxidative stress, fibrosis, and mesangial cell proliferation (Malek et al., 2021). Here, AGT is linked to diabetic kidney disease.