FN1 and renal fibrosis: Danggui Buxue Decoction prevents renal fibrosis through decreasing TIMP-1, TGF-β1 gene, NLRP3 inflammasome expressions and increasing MMP-9 gene expression, leading to decreased collagen IV, collagen I, FN deposition and α-SMA expression in rats (Wei et al., 2012; Wang et al., 2016).