OPG is currently used as a biomarker for liver fibrosis (Coppe et al., 2010; Adhyatmika et al., 2020), while RANKL was recently identified to be part of the SASP in senescent COPD fibroblasts (Woldhuis et al., 2020a). The gene discussed is TNFSF11; the disease is chronic obstructive pulmonary disease.