OPG is currently used as a biomarker for liver fibrosis (Coppe et al., 2010; Adhyatmika et al., 2020), while RANKL was recently identified to be part of the SASP in senescent COPD fibroblasts (Woldhuis et al., 2020a). Here, TNFRSF11B is linked to chronic obstructive pulmonary disease.