SFRP5 and T-cell acute lymphoblastic leukemia: Followed by the decreased DNA (cytosine-5-)-methyltransferase 1 (DNMT1) and DNA (cytosine-5-)-methyltransferase 3a (DNMT3a) expression and the inhibition of Wnt inhibition factor 1 (WIF1), Sex-determining region Y-box (SOX17), cadherin 1 (CDH1) and Secreted Frizzled Related Protein 5 (SFRP5) demethylation, triptolide could inhibit the Wnt pathway, and thereby it inhibits T-cell acute lymphoblastic leukaemia (Ma et al., 2022).