For the treatment of pancreatic cancer, triptolide at the dose of 10–40 nM could inhibit pancreatic cancer cell proliferation through the suppression of hedgehog signaling pathway (Feng et al., 2019), or via the inhibition of plasminogen activator urokinase (PLAU) (Zhao et al., 2020). The gene discussed is PLAU; the disease is pancreatic neoplasm.