Among the UGT1A1 and UGT1A9 regulators, only Pxr was significantly downregulated in colitis mice, suggesting dysregulation of PXR in colitis is associated with the downregulation of UGT1A1 and UGT1A9, thereby potentially resulting in dysfunction of baicalein and puerarin glucuronidation. The gene discussed is NR1I2; the disease is colitis.