Signaling pathways such as SIRT1/NF-κB, SIRT1/p38 MAPK, SIRT1/TGF-β, SIRT1/AMPK may play an important role in maintaining the functioning of cardiomyocytes, influencing the functioning of ID structures during the cardiomyopathy development. Here, TGFB1 is linked to cardiomyopathy.