NFKB1 and neoplasm: α-catenin is a tumor suppressor and can regulate several signaling pathways, for example, inhibit the Wnt/β-catenin pathway, preventing the formation of the β-catenin-TCF-DNA complex and promoting degradation of β-catenin (while p120 catenin has a positive effect on Wnt signal); regulate the Hippo-Yap pathway by blocking YAP dephosphorylation; suppress NF-κB activity by inhibiting ubiquitination and IkB degradation (Li et al., 2015).