Studies have shown that during breast cancer development, phosphoinositide 3-kinase (PI3K), phosphate and tension homology deleted on chromosome ten (PTEN), and p53 play important roles, and PI3K–Akt–mTOR and PTEN pathways are the most important therapeutic targets in breast cancer treatment (McKenna et al., 2018). The gene discussed is AKT1; the disease is breast cancer.