COL2A1 and intervertebral disk degenerative disorder: After eupatilin treatment, it inhibited the increase of the expression of MMPs, p21, and p53 in NP cells and the decrease of the expression of COL2A1 and SOX9, so as to adjust ECM the dynamic balance between anabolism and catabolism, finally reduce the degradation of the ECM, improve the senescence of NP cells, and effectively slow down the progress of IDD.