The pharmacology and pharmacy of CBD have always been enthusiastically investigated by researchers, particularly in neuropsychiatric disorders, such as epilepsy, schizophrenia, anxiety, etc. CBD meditated the CB1, CB2, 5-HT1A, GPR55, PPARγ receptors, and TRPV channels may be explained its extensive pharmacology effects. Here, GPR55 is linked to epilepsy.