GSK3B and neoplasm: PI3K/AKT/GSK3β signaling activity is an essential regulator of diverse malignant behaviour in tumor cells (Hu et al., 2022; Wang et al., 2022), including apoptotic induction (Zhang Y et al., 2022), EMT induction (Zhao et al., 2019; Jiang et al., 2020), and resistance to treatment (Kashyap et al., 2018).