IL6 and neoplasm: However, monocytes in the TME are (Colvin et al., 2022) influenced by tumor-derived cytokines (i.e., M-CSF, IL-10, IL-6, and TGF-β) and differentiate into tumor-promoting M2-type macrophages (i.e., tumor-associated macrophages, TAMs; Quail and Joyce, 2013).