M2-type TAMs are pro-tumorigenic and exert immunosuppressive functions by producing IL-10, induce angiogenesis, and stimulate tumor cells to release MMPs that favor cancer progression by disrupting the ECM and BM (Singh et al., 2017).The inhibitory effect of A-SFE on the polarization of THP-1 to M2 macrophages in the microenvironment and the anti-cancer efficacy of A-SFE in the co-culture environment of M2 and HCT116 cells were investigated in vitro. The gene discussed is IL10; the disease is neoplasm.