However, monocytes in the TME are (Colvin et al., 2022) influenced by tumor-derived cytokines (i.e., M-CSF, IL-10, IL-6, and TGF-β) and differentiate into tumor-promoting M2-type macrophages (i.e., tumor-associated macrophages, TAMs; Quail and Joyce, 2013). This evidence concerns the gene TGFB1 and neoplasm.