The disruption of the basement membrane (BM), which consists of a dense network of crosslinked laminins and collagens, not only facilitates the spread of invading cancer cells or the influx of immune cells into the tumor stroma but also facilitates the formation of new blood and lymphatic vessels that are necessary for supplying tumor tissue with nutrients and oxygen (Augoff et al., 2022). Here, LAMB2 is linked to neoplasm.