Sirt3 knockout in mice resulted in increased levels of EndoMT and reactive oxygen species (ROS), and promoted renal dysfunction, while in Sirt3 knock-in EC-specific transgenic mice, renal fibrosis and EndoMT, as well as oxidative stress, were ameliorated (Srivastava et al., 2021). The gene discussed is SIRT3; the disease is renal fibrosis.