Hyaluronic acid: higher in alveolar and small airway walls Eurlings et al. (2014); Versican: lower in distal parenchyma Annoni et al. (2012); Decorin, biglycan, and lumican: No differences Annoni et al. (2012), lower in peribronchiolar area in severe emphysema van Straaten et al. (1999); Tenascin-C: higher in subepithelial area of large airways and inner layer of small airways Annoni et al. (2012). This evidence concerns the gene BGN and pulmonary emphysema.