Keap1-Nrf2-ARE pathway is associated with OS, which in the organism can lead to cell damage, leading to a variety of chronic diseases in the body, including renal ischemia/reperfusion injury, diabetic nephropathy, pancreatitis, hepatitis, lung ischemia-reperfusion injury, etc. (Majima et al., 2016; Adelusi et al., 2020; Wang et al., 2020). Here, NFE2L2 is linked to hepatitis A virus infection.