When evaluating the prognostic value of these 13 cuproptosis-related genes, expression levels of 9 genes, including FDX1, LIPT1, LIAS, DLD, DLAT, DBT, SLC31A1, ATP7A and ATP7B, were significantly associated with the prognosis of human HCC based on TCGA-LIHC data (Figures 2A-D; S2B). This evidence concerns the gene DLD and hepatocellular carcinoma.