Elegant studies from the Huang’s lab showed that hypoxia-inducible factor 1α (HIF1A) transcriptional signature is generally activated in MDS patient bone marrow stem/progenitors, in major MDS-associated mutations (Dnmt3a, Tet2, Asxl1, Runx1, and Mll1). Here, KMT2A is linked to myelodysplastic syndrome.