Although BMF/MDS are very heterogeneous, the same genomic mutations are frequently found in MDS patients such as mutations in genes related to RNA splicing (SF3B1, SRSF2, U2F1, ZRSR2), DNA methylation (TET2, DNMT3A, IDH1/IDH2), chromatin modification (ASXL1, EZH2), transcription regulation (RUNX1, BCOR), and DNA repair control (p53). The gene discussed is ZRSR2; the disease is myelodysplastic syndrome.