Mutations in the TCA enzyme IDHs (IDH1-IDH2) occur in about 7% of MDS cases, with IDH2 mutations being more frequent (about 4.5%) than IDH1 mutations (about 2.5%).  (44) IDH2 mutations are particularly enriched in the RAEB subtype of MDS. This evidence concerns the gene IDH1 and myelodysplastic syndrome.