Recently, numerous studies have shown that breast cancer-associated fibroblasts play a role in the development and progression of breast cancer, and cancer-associated fibroblasts (CAFs) are the most abundant cellular component of the breast cancer microenvironment, with high expression of many growth factors, such as hepatocyte growth factor, transforming growth factor beta, and fibroblast growth factor. The gene discussed is HGF; the disease is breast carcinoma.