There were many leukemia-related genes in the up-regulated genes of K1 group, such as UBB (P=1.56e-50) (26), MIF (P=2.76e-50) (27), DRAP1 (P=1.72e-49) (28), RPS25 (P=1.9e-49) (29), EIF3K (P=4.77e-49) (30), SSNA1 (P=1.27e-48) (31), GPX4 (P=3.01e-48) (32), PHB2 (P=7.13e-48) (33), NME2 (P=2.44e-47) (34) or CFL1 (P=4.07e-47) (35). The gene discussed is NME2; the disease is leukemia.