Recently, nomograms were proposed to improve LARC prognosis prediction (7–10), using indexes such as age, carcinoembryonic antigen (CEA), carbohydrate antigen 19–9 (CA19-9), pathological tumor stage (ypT), pathological nodal stage (ypN), and tumor regression grade (TRG). The gene discussed is CEACAM5; the disease is neoplasm.