BCR and chronic myelogenous leukemia, BCR-ABL1 positive: In the WHO classification, CML and aCML belong to myeloproliferative neoplasms, the distinction is that CML is defined as BCR-ABL1 fusion-positive resulting from t (9, 22) (q34; q11), while aCML is rare and characterized molecularly with BCR-ABL1 fusion-negative, and it is emphasized that accurate histological diagnosis has been to be the key to predict the prognosis of the disease (1, 4).