FGFR1 and lymphoma: In a mouse model of ZNF198-FGFR1, T-cell receptors on the surface of tumor cells were found to have an α-deletion hindering the recruitment of CD3, preventing the maturation of CD4 (+)/CD8 (+) double-positive T cells, and upregulating BCL2, IL-7 receptor-α and IL-2 receptor-α in tumor precursor cells, allowing them to escape apoptosis in the thymus, which may be one of the reasons why this fusion more easily induces T-lymphocytic leukemia/lymphoma phenotype (68).