As eIF2α S51 phosphorylation was predominantly mediated by PKR in prostate cancer cells, and that we had unexpectedly observed activation of the JNK1/2 pathway in prostate cancer cells, we determined whether the JNK1/2 pathway was being regulated by GZ17-6.02 via a PKR-dependent mechanism. The gene discussed is MAPK8; the disease is Familial prostate cancer.