When interrogating the mechanism of action of ABTL0812 in glioblastoma models, we demonstrated that ABTL0812 induces TRIB3 and consequently inhibits Akt/mTORC1 axis, as indicated by a reduction of p-Akt and of the mTORC1 substrate p-p70S6K. Here, RPS6KB1 is linked to glioblastoma.