AKT1 and glioblastoma: Hyperactivation of the PI3K/Akt/mTOR (PAM) pathway is commonly observed in human cancers including colorectal cancers (27), head and neck cancer (28), non-small cell lung cancer (29), endometrial cancer (30) as well as glioblastoma (31), and results in induction of cell growth, survival, adhesion, and migration.