ABTL0812 kills cancer cells through the induction of cytotoxic autophagy by a dual mechanism of action: i) inhibition of Akt/mTORC1 axis by overexpressing TRIB3 (13), and ii) induction of endoplasmic reticular (ER) stress and, consequently, of the Unfolded Protein Response (UPR) (14). Here, TRIB3 is linked to cancer.