Furthermore, Arid5a enables mesenchymal tumor models of PDAC and CRC to facilitate immune evasiveness via promoting tumor infiltration of immunosuppressive granulocytic MDSCs (gMDSCs; also known as polymorphonuclear MDSCs (323)) and Tregs (324), and suppressing the recruitment and activation of anti-tumor effector T cells (322). The gene discussed is ARID5A; the disease is colorectal carcinoma.