In the same way, CCL2 produced by tumor cells and CSF1 produced by tumor-associated fibroblasts contribute to the generation of M2-like macrophages (263, 264), and CXCL1 production by tumor cells has been linked to increased myeloid cell populations and decreased tumor infiltration of cytotoxic CD8+ T cells (265). This evidence concerns the gene CSF1 and neoplasm.