IL6 and neoplasm: In addition, cancer-associated inflammation induced by IL-6, IL-1, IL-17, IL-22, and IL-23 is not only a driver of carcinogenesis, but is also associated with tumor progression by inducing EMT, whereby epithelial cells acquire malignant mesenchymal properties, such as detachment from other cells, invasion into adjacent tissues, and accelerated metastatic spread to other distant organs (21, 271–275).