A study using PDAC model KPC (Pdx1-cre; LSL-KrasG12D;Tp53R172H/+) mice, in which TWIST and SNAIL were independently conditionally knocked out, resulting in Pdx1-cre; LSL-KrasG12D;Tp53R172H/+;Twist1flox/flox and Pdx1-cre; LSL-KrasG12D;P53R172H/+;Snai1flox/flox mice, respectively, found that although EMT was suppressed, the deficiency of SNAIL or TWIST did not affect tumor progression, regional invasion, or dissemination. Here, TWIST1 is linked to neoplasm.