TGFB1 and neoplasm: However, some lines of evidence indicate that senescent cells in the TME can produce a senescence-associated secretory phenotype (SASP), mediated by NF-κB and CCAAT/enhancer-binding protein-β, including the secretion of proinflammatory cytokines (IL-6 and IL-8), chemokines (monocyte chemoattractant proteins [MCPs], macrophage inflammatory proteins [MIPs], TGFβ, and granulocyte–macrophage colony-stimulating factor [GM-CSF]), and proteases (84), and play protumorigenic roles during tumor progression (85).