A series of our studies have identified that high protein levels of ARF6, AMAP1, and EPB41L5 were associated with invasiveness of several kinds of solid tumors, including breast cancer, clear cell renal cell carcinoma, lung adenocarcinoma, and PDAC and importantly that these expression levels were statistically correlates with poor prognosis (94, 145, 146, 149). The gene discussed is ARF6; the disease is breast cancer.