A study using PDAC model KPC (Pdx1-cre; LSL-KrasG12D;Tp53R172H/+) mice, in which TWIST and SNAIL were independently conditionally knocked out, resulting in Pdx1-cre; LSL-KrasG12D;Tp53R172H/+;Twist1flox/flox and Pdx1-cre; LSL-KrasG12D;P53R172H/+;Snai1flox/flox mice, respectively, found that although EMT was suppressed, the deficiency of SNAIL or TWIST did not affect tumor progression, regional invasion, or dissemination. This evidence concerns the gene SNAI1 and neoplasm.