Following univariate Cox regression analysis, CDC25C [hazard ratio (HR): 1.26, 95% CI: 1.03-1.54, p = 0.022], NEIL3 (HR: 1.31, 95% CI: 1.07-1.6, p=0.009), H2AFX (HR: 1.23, 95% CI: 1.01–1.51, p=0.038), NBN (HR: 1.44, 95% CI:1.18-1.76, p=0.00), and XRCC5 (HR: 1.30, 95% CI: 1.06-1.59, p=0.01) were risk factors for NSCLC prognosis (Figure 7D). The gene discussed is H2AX; the disease is non-small cell lung carcinoma.