Firstly, we evaluated the mRNA expression of six DDR-related genes in NSCLC tissues in GEPIA, which demonstrated that CDC25C, NEIL3, H2AFX, NBN, XRCC5 and RAD1 were all significantly higher expressed in NSCLC cancer tissues compared to with normal lung tissues (Figure 9A). This evidence concerns the gene XRCC5 and non-small cell lung carcinoma.