By analyzing LOGpc (https://bioinfo.henu.edu.cn/DatabaseList.jsp) and Kaplan–Meier plotter (https://kmplot.com/analysis/) databases, LDHC was found to be oncogenic in BC, RCC, LUCA, uterine corpus endometrial carcinoma (UCEC), thymoma (THYM), and pheochromocytoma and paraganglioma (PCPG), with high LDHC expression being associated with poor prognosis. Here, LDHC is linked to hereditary pheochromocytoma-paraganglioma.