NLE1 and amyotrophic lateral sclerosis: In patients with sporadic ALS, downregulation of exosomal miR-1825 and miR-1234-3p that target NXPH3 and NLE1 gene involved in pathogenesis of ALS have been seen, suggesting involvement of these genes in pathogenesis of ALS (Taguchi and Wang, 2018; Chen et al., 2021).