EVs isolated from AD patients transferred toxic Aβ to neurons with subsequent toxic effect on the recipient cells (Falker et al., 2016; Sardar Sinha et al., 2018). Inhibition of EV significantly reduced tau propagation in vitro and in vivo (Asai et al., 2015). EVs from AD patients induced tau pathology in mice (Winston et al., 2016). Here, MAPT is linked to Alzheimer disease.