To identify more subtle genetic changes, groups have performed whole-exome sequencing on many of the hES cell lines listed on the US National Institutes of Health registry and reported the acquisition of dominant negative p53 mutations, a mutation associated with many cancers, for several hES cell lines (Merkle et al., 2017), and other genomic changes associated with cancer and tumorigenesis (Merkle et al., 2022). The gene discussed is TP53; the disease is cancer.