Mutations altering exon 10 splicing can increase the levels of 4R or 3R Tau which are also related to several neurodegenerative diseases, e.g., fronto temporal dementia and progressive supranuclear palsy (Chen et al., 2010; Qian and Liu, 2014; Bachmann et al., 2021; Stamelou et al., 2021). Here, MAPT is linked to frontotemporal dementia.