Interestingly, phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) are over-expressed in CRCs (Bahrami et al., 2018), while the PI3K/Akt/mTOR activation could prevent PD via reducing the dopaminergic neuron apoptosis (Leikas et al., 2017). This evidence concerns the gene AKT1 and Parkinson disease.