In addition, p-tau181 was not associated with Aβ in either nAMD or cataract patients’ AH, which might be due to the replacement of local sources of NfL and Aβ proteins in the eyes, such as the release of NfL from the retinal nerve fiber layer or amyloid plaques found in the retina independent of those found in the brain (Jin et al., 2019). The gene discussed is NEFL; the disease is cataract.