1–Chronic kidney disease. 2–Established ASCVD. 3–High-risk of ASCVD; defined as having a 10-year ASCVD risk score ≥20%, having stenosis, or left ventricular hypertrophy. 4–BMI ≥ 27 Kg/m2. 5–HFrEF (< EF <45%). 6–Patient is on two other antidiabetic medications*.GLP-1 RA for patients with T2DM and one of the following: 1–Chronic kidney disease. 2–Established ASCVD. 3–High-risk of ASCVD; defined as having a 10-year ASCVD risk score ≥20%, having stenosis, or left ventricular hypertrophy. 4–BMI ≥ 27 Kg/m2. 5–Patient is on insulin. 6–Patient is on two other antidiabetic medications*. The gene discussed is INS; the disease is chronic kidney disease.