Such questionnaires might be limited by recall bias, untruthful answers, etc. Third, IgE sensitization was simply defined as total IgE > 150 KU/L, as it was impossible to distinguish IgE levels caused by food allergy and/or other pathologies such as parasitic infection, auto-immune disorders, and neoplastic disease in samples of NHANES; it is needed to know that IgE sensitization has a certain expansion in this paper. The gene discussed is IGHE; the disease is food allergy.