PA Outcomes:- PA: minutes/wk for leisure time PACV outcomes-Cardiorespiratory fitness (VPeakO)-BMI-Waist circumference-Lean and fat body mass-Insulin sensitivity index-Lipid panel: LDL, HDLOthers:Depression-Health-related QOL-Pain related to PA and wheelchair use. This evidence concerns the gene INS and major depressive disorder.