However, there are few published studies on prognostic indicators and therapeutic targets in glioma, so our results reveal a novel role for four genes (IL4I1, CYP1A1, OGDHL, and ASMT) in this context, and that a predictive model that incorporates these genes is able to predict the prognosis of individuals with glioma. The gene discussed is IL4I1; the disease is glioma.