A potential bradykinin antagonist, reduced the major pathophysiological features of allergic asthma, in part by acting on TGF-β1/Smad signaling pathways (Jang et al., 2012); attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release (Bui et al., 2017). This evidence concerns the gene KNG1 and allergic asthma.