For example, transcripts exhibiting interactions between genotype and diet (Table 2 and Supplementary Figure 2) include Adora2a, an adenosine receptor involved in inflammation, and regulation of sleep, along with genes involved in metabolic and neurodegenerative diseases (Adcy8, Lrrk2), as well as in neuronal excitability and synaptic activity (Calb2, Dlx1). The gene discussed is ADCY8; the disease is neurodegenerative disease.