In the continuous analysis, per doubling of FGF23 was associated with increased risks of MI (<i>RR:</i> 1.08, 95%CI: 0.94-1.25), stroke (<i>RR:</i> 1.21, 95%<i>CI</i>: 0.99-1.48), HF (<i>RR:</i> 1.24, 95%<i>CI</i>: 1.14-1.35), CVD events (<i>RR:</i> 1.12, 95%<i>CI:</i> 0.99-1.27), cardiovascular mortality (<i>RR:</i> 1.43, 95%<i>CI:</i> 1.09-1.88), all-cause mortality (<i>RR:</i> 1.37, 95%<i>CI:</i> 1.15-1.62). The gene discussed is FGF23; the disease is Stroke.