cTnT-hs, a biomarker reflecting cardiovascular endothelial integrity, was associated with an increased risk of major bleeding regardless of OACs patterns in the ARISTOTLE trial (19), and this association remained significant after adjusted cTnT-hs level by the components of the HAS-BELD score in the ENGAGE AF-TIMI 48 trial (14). Here, MAP3K14 is linked to atrial fibrillation.