Protein kinase C (PKC) also promotes NOX5 overexpression, regulates the endothelial cyclooxygenase-2 (COX-2)/prostaglandin-2 (PGE2) axis, causes ROS overproduction, and accelerates the progression of myocardial remodeling by activating the post-myocardial infarction (MI) inflammatory response (80, 81). This evidence concerns the gene PTGS2 and myocardial infarction.