NOX4 can be involved in the pathogenesis of various cardiovascular diseases and myocardial remodeling as a central component of endoplasmic reticulum stress, participating in the oxidation of sarcoplasmic reticulum calcium ATPase (SERCA), increasing intracellular calcium ion transport, mediating myocardial electrophysiological activity, activating oxidative stress, and reducing autophagy (65). The gene discussed is NOX4; the disease is cardiovascular disorder.