FMO5 and heart failure: In this review, the basic pathophysiological process of myocardial remodeling was explored regarding the NADPH oxidase family mediating related signaling pathways through multiple signaling targets, upregulating oxidative stress levels, activating increased ROS expression levels, and severely affecting pathological changes such as cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis, and causing changes in myocardial structural and energy metabolic remodeling, leading to the deterioration of heart failure.