Many factors could enhance the expression of NOX2, such as Hyperglycemia, hyperlipidemia, ischemia-reperfusion injury, Ang II, ET-1, transforming growth factor β (TGF-β), IFN-γ, PDGF, and VEGF (6, 7, 31, 34). This evidence concerns the gene TGFB1 and Hyperglycemia.