NOS3 and endothelial dysfunction: Salusin-β inhibits NOX-mediated ROS production, activates eNOS and NO production, causes dysregulation of the balance of contractile and vasodilator factors released from the vascular endothelium (101), improves endothelial dysfunction, cardiovascular remodeling, and cardiac dysfunction, and promotes early depolarization of rabbit cardiomyocytes by activating the calmodulin-dependent protein kinase II (CaMKII) pathway.